INDICATIONS

REBLOZYL is indicated for the treatment of anemia in adult patients with beta thalassemia who require regular red blood cell (RBC) transfusions.

REBLOZYL is indicated for the treatment of anemia failing an erythropoiesis stimulating agent and requiring 2 or more red blood cell units over 8 weeks in adult patients with very low- to intermediate-risk myelodysplastic syndromes with ring sideroblasts (MDS-RS) or with myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T).

REBLOZYL is not indicated for use as a substitute for RBC transfusions in patients who require immediate correction of anemia.

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DOSING AND ADMINISTRATION: ADMINISTERING REBLOZYL

Instructions for administering REBLOZYL1

REBLOZYL should be reconstituted and administered by a healthcare professional

Prior to injection, allow solution to reach room temperature for a more comfortable injection.

First step icon

Verify correct dose for the patient

  • Calculate the exact total dosing volume of 50 mg/mL solution required for the patient
Second step icon

Plan and prepare for injection

  • Slowly withdraw the dosing volume of the reconstituted REBLOZYL solution from the single-dose vial(s) into a syringe
  • Divide doses requiring larger reconstituted volumes (ie, >1.2 mL) into separate, similar-volume injections and inject into separate sites
Third step icon

Administer subcutaneously

  • If multiple injections are required, use a new syringe and needle for each SC injection
Administer REBLOZYL® subcutaneously via the back of an upper arm, the abdomen, or a thigh

NOTE: Discard any unused portion. Do not pool unused portions from the vials. Do not administer more than 1 dose from a vial. Do not mix with other medications.

DOSING AND ADMINISTRATION: ADMINISTERING REBLOZYL

Instructions for administering REBLOZYL1

REBLOZYL should be reconstituted and administered by a healthcare professional

Prior to injection, allow solution to reach room temperature for a more comfortable injection.

First step icon

Verify correct dose for the patient

  • Calculate the exact total dosing volume of 50 mg/mL solution required for the patient
Second step icon

Plan and prepare for injection

  • Slowly withdraw the dosing volume of the reconstituted REBLOZYL solution from the single-dose vial(s) into a syringe
  • Divide doses requiring larger reconstituted volumes (ie, >1.2 mL) into separate, similar-volume injections and inject into separate sites
Third step icon

Administer subcutaneously

  • If multiple injections are required, use a new syringe and needle for each SC injection
Administer REBLOZYL® subcutaneously via the back of an upper arm, the abdomen, or a thigh

NOTE: Discard any unused portion. Do not pool unused portions from the vials. Do not administer more than 1 dose from a vial. Do not mix with other medications.

Reference: 1. REBLOZYL [US Prescribing Information]. Summit, NJ: Celgene Corporation; 2022.