REBLOZYL should be reconstituted and administered by a healthcare professional1
- Reconstitute REBLOZYL with Sterile Water for Injection, USP only
|Vial size||Amount of Sterile Water for Injection, USP required for reconstitution||Final concentration||Deliverable volume|
|25 mg vial||0.68 mL||25 mg/0.5 mL||0.5 mL|
|75 mg vial||1.6 mL||75 mg/1.5 mL
Important considerations for REBLOZYL reconstitution1
- Reconstitute the number of REBLOZYL vials to achieve the appropriate dose based on the patient’s weight
- Use a syringe with suitable graduations for reconstitution to ensure accurate dosage
Adhere to the following steps to properly reconstitute REBLOZYL1
Reconstitution instructions for REBLOZYL for SC injection
1. Add Sterile Water for Injection, USP.
Reconstitute with Sterile Water for Injection, USP using volumes described in the Reconstitution Volumes table above with the stream directed onto the lyophilized powder. Allow to stand for 1 minute.
2.Discard the needle and syringe used for reconstitution.
The needle and syringe used for reconstitution should not be used for SC injections.
3. Mix and wait.
Gently swirl the vial in a circular motion for 30 seconds. Stop swirling and let the vial sit in an upright position for 30 seconds.
Inspect the vial for undissolved particles in the solution. If undissolved powder is observed, repeat step 3 until the powder is completely dissolved.
5. Mix and wait.
Invert the vial and gently swirl in an inverted position for 30 seconds. Bring the vial back to the upright position, and let it sit for 30 seconds.
Repeat step 5 seven more times to ensure complete reconstitution of material on the sides of the vial.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. REBLOZYL is a colorless to slightly yellow, clear to slightly opalescent solution, which is free of foreign particulate matter. Do not use if undissolved product or foreign particulate matter is observed.